Moreover, the COVID-19 pandemic highlighted the vulnerabilities in the global API supply chain. It underscored the importance of securing local supply chains and investing in domestic production capabilities. As a result, there is a growing trend toward nearshoring and investment in local API manufacturing facilities to reduce dependency on foreign sources.
Once APIs are formulated into FPPs, stability testing becomes even more critical. FPPs might contain various excipients that can interact with the active ingredient, influence its stability, and affect the overall product performance. For example, the choice of excipients, packaging materials, and the manufacturing process can all impact the shelf life of a medication.
In terms of spill and leak procedures, the MSDS outlines appropriate actions to take in case of accidental release. This includes evacuation of the area, containment of the spill, and neutralization or cleaning procedures. Proper training in these emergency protocols is essential for all employees who might encounter this chemical to prevent injuries and mitigate environmental impact.